The Crackin' Backs Podcast

We Don’t Lose Our Minds to Alzheimer’s—We Lose Our Molecules

• Dr. Terry Weyman and Dr. Spencer Baron

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What if Alzheimer’s isn’t something we merely “treat” but a biochemical imbalance we can restore? On this episode of Crackin’ Backs, we go deep with neuroscientist Dr. Dayan Goodenowe — a pioneer in the science of plasmalogens, memory, and brain restoration.

We begin by peeling back his personal journey: what sparked his fascination with Alzheimer’s, biochemical disease, and the hidden chemistry of consciousness. Then we dive into the heart of the episode:

  • What are plasmalogens and why are they essential for brain health, memory, and cognition?
  • How could plasmalogen deficiencies be the missing link in dementia and Alzheimer’s disease?
  • Which other biochemical pathways may hold keys to closing the gap between molecules and awareness?
  • Can restoring a brain’s chemistry truly void the myth that Alzheimer’s is irreversible?

You’ll hear stories, concrete science, and a vision for the next frontier of Alzheimer’s and other disease prevention, possible reversal, and cognitive restoration.

Whether you’re caring for someone with dementia, curious about brain longevity, or fascinated by the intersection of biochemistry and consciousness — this episode offers new hope and actionable insight.


 About Dr. Dayan Goodenowe, PhD

Dr. Goodenowe is a trailblazing neuroscientist, inventor, and the driving force behind Prodrome Sciences. He has led more than 15 years of research into metabolic biomarkers, Alzheimer’s, and neurological disease. His groundbreaking work has identified plasmalogen deficiency as a potential causative factor in Alzheimer’s and dementia, shifting the conversation from damage control to restorative biochemistry. He is also the author of Breaking Alzheimer’s: A 15-Year Crusade to Expose the Cause and Deliver the Cure.

Dr. Goodenowe founded the Dr. Goodenowe Restorative Health Center, which specializes in biochemical restoration protocols for neurologic conditions including Alzheimer’s, ALS, Parkinson’s, and cognitive disorders.

He has published on topics such as plasmalogen supplementation in mild cognitive impairment, serum plasmalogens and Alzheimer’s biomarkers, and metabolic correlates of aging and cognition.

 Learn More & Dive Deeper

We are two sports chiropractors, seeking knowledge from some of the best resources in the world of health. From our perspective, health is more than just “Crackin Backs” but a deep dive into physical, mental, and nutritional well-being philosophies.

Join us as we talk to some of the greatest minds and discover some of the most incredible gems you can use to maintain a higher level of health. Crackin Backs Podcast

Dr. Terry Weyman:

All right. Well, I'm very excited about this show, especially with some personal reasons. But we're going to talk about Alzheimer's today. And people talk about treating Alzheimer's, but you dr, good, now talk about restoring the brain chemistry, which is exciting for all of us. And we want to peel back the layers before we get into the science. I want to hear about the early journey which fascinated you enough to devote your life to this amazing puzzle. I come

Dr. Dayan Goodenowe:

from formal training, so my PhD is in psychiatric medicine, looking at the biochemical mechanisms of disease of the brain, you know, Alzheimer's, Parkinson's, you know, so on depression, anxiety. And then my career, we started looking at the biochemistry and the structure. Did a lot of work in the pharmaceutical industry, looking at drug design, how to interact, how molecules interact in the brain side. Do supercomputing work? And from that one step leads to another, is understanding, in the 90s, this whole genomics revolution was happening, and, you know, we had companies like Affymetrix, and we did, you know, parallel sequencing technology, a lot of was on the animals in the plant world as well as the human world. And we had this ability to look at genomics in a very thorough, comprehensive way, but we didn't have any way to measure biochemistry. Okay, so, so all of the proteins in your body and all the transcripts, they all come from your DNA. And it's, it's, you know, obviously it's fixed other than, you know, epigenetic modifications that can occur in it. But the biochemistry in our world is infinite, so every single protein and everything in your body can be ultimately mapped back to a gene sequence. Okay, and so that goes there, but the biochemistry that the glucose and the fatty acids and all those molecules, those don't come from your genome, okay, glucose in your body is the same as glucose in a plant, okay. And so biochemistry is universal across all types of living organisms, and the number of molecules biochemicals is fundamentally infinite. It's larger than the number of particles in the universe. So I can't just create a library. Say, You know what? I'm going to just go out and identify every single possible molecule, and I'm going to create a list, which is what we did with genes, right? We say we can just so then we get these, these gene chips, or whatever it is, which kind of gives us some sort of comprehensiveness. And so there's no way to actually do that biochemically. So I was first invention was what's called ion cyclotron mass spectrometry, this non targeted metabolomics. We use this high field magnet to measure 1000s of molecules simultaneously with a very high degree of resolution, very high degree of accuracy. So we could identify molecules without any prior knowledge. So no a priori knowledge. We had this true, non targeted approach. And science was changing from pure hypothesis driven research, where you say, I have an idea, I want to test an idea, to hey, let's look at the data. And from the data, can we derive where this came from? And this is where this, this comprehensive biochemistry came in. And early on in my career, it was focused on diagnostics and therapeutics from a pharmaceutical perspective, because this technology is truly a universal diagnostic and so talking about aging ourselves like we're talking about a tricorder, we can predict when you'll die. Fundamentally, we can predict virtually every disease on the planet in advance. These are called prodromes, because we if your body is different, like if you're here and you're you're, you know, your friend next to you has colon cancer, well, you know you're physically different. So since you're physically different, there's something physically different with the two of you. There has to be a biochemical signature that corresponds to that right? It's just obvious. And if we can't see it, we're just not looking hard enough or looking in the right place. And so this created that kind of technology you could find that. And so this was pretty exciting. So we could, we could, you know, very clear signatures of colon cancer, pancreatic cancer, ovarian cancer, Alzheimer's, Parkinson's, children with autism, and so I published a whole stream of patents on this biochemical diagnostics of disease. And then so I'll get to the point in a minute here. So the point is that so initially you thought that disease is something that happens to you, right? So colon cancer, there's got to be a tumor in your body, and this tumor is doing something. And so you think that the diagnostic test is actually measuring what the tumor is doing on the body. This is what I thought, right? We had this great technology. So I did this clinical trial in Japan with a group out of Osaka, where we looked at people before they had colon when they had colon cancer, had surgical removal, we're told they were now cancer free, and measured their biomarkers before and after, and found that the biomarkers didn't change. The colon cancer diagnostic markers were the same after the tumor was removed as it was before the tumor. And so this was we were we weren't expecting this. We. Were thinking, okay, to get rid of the tumor, the biomarkers can go back to normal. So since they wouldn't, didn't believe this, we did a study again in a different university in Japan, out of Chiba University, and got exactly the same results. And this was the first really big aha moment in that we've got this all wrong. We don't actually get disease. We lose health. Okay? And it's a loss of health that leads to disease other than a bacterial infection, but other all these other chronic diseases are caused by our we lose something. It's not that we get a disease. We actually lose health. And so these prodromes predict the future. So instead of diagnosing cancer, what we were diagnosing was people who had a high likelihood of getting cancer, okay, and so. And so. This also means that we can actually change the future. So when you change the underlying physiology, the program, the future changes. So your your future is determined by your actions today. And so you change your actions today, you change your future. And this happens at the biochemical level. And so this technology was used, literally, I have over 100,000 blood samples in my freezers here in Temecula. And so we did, like a 6000 person clinical trial. We could detect colon cancer, you know, at stage one and zero. And all this work in pancreatic cancer over like no woman should ever die of ovarian cancer, we can diagnose it well in advance, they can get have their children, remove their fallopian tubes, no more cancers, issues. So there's so many things. So this got very frustrating to me. So, you know, more patents, more publications. And it really became, you know, at some point scientific masturbation is like, how smart can I be, and how many things can I do? Okay, but I'm not getting any result to the end of the day. You know, there's an instant gratification, but nothing's actually coming of this, and because we did all this work. So this is where this concept of prodromes and understanding now we need to be able to interact with them, but we're really, what we're doing is we're doing Biochemical Engineering. Okay? It's basically like you do, you know, fertilizing plant, or you're doing brewery in terms of making your beer and your wine, the human biochemistry of the body. We can intervene at the biochemical level, and we can change outcomes and change we can restore the health. And this is the other part of the process. Is that we don't have to play God. We don't say, You know what? I know sciences are quite arrogant in their thinking that we develop a drug, develop a drug like Prozac, like fluoxetine and SSRI, and it's designed to interact with with a serotonergic receptor, right? And we're going to tweak, we're going to come in with a drug molecule, and we're going to affect a receptor, we're going to block an enzyme, like a statin, for example, for HMG COA enzyme, and then the body has to kind of adapt to that. But the point is that the body is actually designed to heal itself, if you can give it what wants, right? And this is a huge work with autism. When we restore the neurodevelopmental process by restoring the myelination of the brain, and these children get better, quite dramatically. And this is what this whole process is. So back to the Alzheimer's thing, where it got really kind of, kind of started a whole other cascade is we're using this advanced technology in people with dementia. Found a class of molecules that were reproducibly low in people that had dementia, and these molecules were called plasmalogens. And me, being, you know, formally trained neurochemists, for crying out loud, didn't even know what these things are. So I was never taught about plasmalogens in school. And we're talking about a class of molecules that makes up literally 30% of your brain, up to 70% of the myelin sheath, 50% of the lipids in your heart. Phospholipids are plasmalogens. So when people get myocarditis and these issues that we have, high levels in kidneys, extremely high levels in your eyes and retina. And I had no idea what these things were. I things were. So seriously, I was, this was in the early 2000s and I was googling what these molecules were, and I found out, well, we didn't know about these things, like, There's literature, I think they were discovered in the 20s, and we have these rare diseases in children, like leukodystrophies and peroxisomal disorders. And we know that if you have a plasmalogic deficiency, you die, okay? Basically, these children die within a few years of life. If they can't make plasmalogens, we know the absolute dependence on human life. It's one of the critical molecules of our of our membranes and structures. So the point so now I found out these plasmalogens, they correlated with the severity of dementia, and then they also predicted future dementia. So then we did numerous trials, huge work in Chicago with the Rush University program of aging. And so we have all these individuals enroll in this long term longitudinal trial, and they enroll being healthy. And rush does extensive testing, Parkinson's, there's 19 psychometric tests they do every year. And then these individuals, they donate their brains to science when they're done. And so this thing, this project, has been going on for like, 20 some years, and so we have all their blood samples in our freezer. So we've run all these longitudinal studies, and with these plasmologists, we were able to predict people who did not. Have dementia, but would get dementia in the near future if they had low plasmalogens. The other scary thing that happened, so we did all this work, and we thought, well, you know what? This study has been going on quite a long time, and it's been done with the elderly population. We could probably measure all cause mortality. What's, what's the relationship between plasmalogens and all cause mortality turned out to be enormous, bigger than dementia and anything else. It was like a 30 year difference in lifespan. Like a 65 year old with low plasmalogens has the same five year survivability as a 95 year old with high plasma intelligence. So you take you can take a 65 year old and a 95 year old based upon their plasmalogen levels, they have the same five year so a 95 year old has the same probability. And if you're 95 years old and you have high plasmalogens, you have about an 80% chance of making it to your 100th birthday. This is just without any any low plasmalogens, you have an 80% chance of dying. You only have a 20% chance. So we're talking enormous longevity issues

Dr. Terry Weyman:

here, Hey, Doc, for the for the lay person that's listening, can you actually tell us, or break it down, what a plasmalogen is,

Dr. Dayan Goodenowe:

so it's a phospholipid. So the human body has about 30 trillion cells, and you think about so we're not a bowl of soup, right? So how does the body compartmentalize and structure this thing called the body that started off with a single cell, right? We all started from a single cell that developed and into this complex organism that you see in front of you. But there's 30 trillion plus cells in the human body, and what separates one cell from another cell is the biological membrane. That's what houses it. It's a three dimensional structure that like the walls on your house. So you get this compartmentalization, so that lipid bilayer is called the phospholipid bilayer, and so you're the way your body makes biological walls, is with phospholipids and cholesterol and some other things, right? But FOSS lipids are the main component, and this allows, this separates one cell from another, and it determines what goes in a cell, what goes out of a cell. But then you get further compartmentalization inside the cell. So then you have your nucleus, you have mitochondria, peroxisomes, Golgi, you know, endoplasmic reticulum, all these different cells parts and the body further compartmentalizes, just like you do in your house. So you you have your kitchen separated from your bathroom from your bedroom, okay, so you can do different activities in different areas without affecting them. And it gets so good that we can have a refrigerator right next to our our stove. So you can have one part of your house at minus 20 in your deep freeze, and right next to it, you could be cooking, you know, something at high temperatures. And so this is all done by compartmentalization. So how the body compartmentalizes itself is by these biological living membranes, and they maintain them. And this is how synapses are formed and how neurotransmitters are passed back and forth. So phospholipids are what makes that membrane. So plasmalogens are critical component of it. So when you become deficient in plasmalogens, your membranes become stiff, okay? This is where it's linked to atherosclerosis, your ability with these neurotransmitters, the flexibility, like your bare reflex, your heart rate variability, which is, which is driven by the bare reflex. That's all, all the sub the you know, the suppleness of your membranes are so critical. So when you lose plasmalogens, you lose that level of structure. And then the other really quirky thing about these things is that they're your body's main antioxidant, okay, orders of magnitude more than a vitamin E or anything else. And so as soon as you get an oxidative stress, your body pumps them so that they're stored in your membrane, so you have this huge reservoir of them, and it'll dump them out, and it has a what makes them special is this ether bond. It's called a vinyl ether bond, and it's like a fuse. If you think of your car guy, it's like a fuse, and it bursts before anything else. So rather than creating a fire, the fuse breaks. Well, you can think of plasmalogens like a fuse. And when you get oxidative stress, that vinyl bond breaks apart and neutralizes it, so it so it completely neutralizes peroxides, for example. The problem is you can't eat them. So you think, Wow, that's great. So we have all this plasmalogens in our body. So animals like your your steak and things have to have plasmalogists. So why can't I just eat a bunch of good animal products and get all the plasmas I need? Well, that secret that they do with the vinyl, eat your bond soon as it hits the hydrochloric acid in your stomach, which is concentrated hydrochloric acid, pH of two, right? Like it'll it'll dissolve metal, like your stomach acids, like people forget. It's the first act of prevent. It's the first thing that your body uses to neutralize all the stuff that we eat right before it gets digested. So these plasmalogies Get burst apart. There's only really one natural source of plasmalogens in our food supply and their plasmalogen precursors. So think about Parkinson's. When people take the drug called L dopa, right? They don't. Parkinson's is a disease with dopamine deficiencies, but we don't give people dopamine. We give them a precursor to dopamine. We give them more. Molecule called L dopa, which is, by the way, a supplement, right? We call it a drug, but it's a biochemical supplement. It's like an acetylcysteine, like, that's what drug is for Parkinson's, we just call it a drug because they like to use it as a drug, but it's basically a supplement. Okay? And so the So, same thing with plasmalogens. We can't eat the intact plasma allergen. What we do is we eat a precursor, and it's present in human breast milk. So human breast milk is one of the few places on earth that has these plasma allergen precursors, which is why breastfeeding, specifically for the first six weeks a month, first six months of life, has a tremendous association with increased brain brain development in white matter. And so back in the early 2000s when I discovered this plasmalogen situation, and realized from the 70s, we knew about the severity of plasminogen deficiencies, and people were trying to find a way to restore them, like there's old molecules like camel alcohol and battle alcohol, but you had to take massive quantities of them, and they didn't really work. And so I'm also a synthetic organic chemist. So my background in psychiatric medicine, but my first degree is actually in synthetic is in chemistry. So I actually make things. And so my job in the early 2000s was figuring out, how do we get plasma allergens into the human body? So I invented plasmalogen precursors, as we could structurally provide specific plasmalogens called these plasmalogic precursors, and we have two of them now that we primarily use one with oleic acid, which will make a nine for the myelin. It's really a calming, restorative molecule for the heart and brain. And then we have a performance enhancing plasmalogen, which is the Omega three, so with DHA. So the DHA is pretty cool. If you take this stuff, it's, um, it increases the membrane fusion, so increases all your synaptic release, which is also your neuromuscular junction. And this is where it gets really interesting in Alzheimer's disease. So these plasma so that's what these plasma molecules do. So the Omega nines are for the structure of the membrane, like the plastic coating, if you will, structure of your of your big, of your heart. And then the Omega threes are really activating. They increase cellular activity. They increase synaptic function quite dramatically. And then that activity is what allows the brain to regrow. So now I I've shown I've had a woman with with multiple sclerosis, who's been blind for 30 years, who can now see? Okay, we've restored her vision after 30 years of blindness in MS, and we, with advanced MRI, we can actually watch her brain regrowing itself. And all we've done is allowed that optic nerve and the oligodendrocytes to do their job, and it starts remyelinating, and she starts redeveloping her site from her loss, and it grows. And so when you increase the synaptic activity, and you provide the building blocks for the cells to make the things they're supposed to make. My brain. I'm 56 now. I've systematically shown my brain reversal, so we can now unambiguously, without a doubt, stop brain aging. Okay, it's quantitative immortality. We're talking about. We have absolutely unambiguous and then this over and over again, we can see this cortical regrowth and restoring structure and function in human brain. Well, that's kind of where the story goes. So then Alzheimer's disease, so your brain has many systems, and we get complicated. It's people think about it like a computer, but it's not really a computer. It's a wiring diagram, okay, it's like a wiring harness from your car with, you know, from the front to the back. And it's, it's, it's how wires are connected. And there's different systems. You have two main systems that glutamate and GABA, and there's a whole bunch of sub secondary systems like serotonergic, dopamine, acetylcholine. So in Alzheimer's disease. It's the acetylcholine system. Okay? So people take drugs like Aricept, which is acetylcholinestera blocker, or they take a agonist like mantene, or something like that. So we want to stimulate the the cholinergic system. What's interesting with this system is it's kind of your master conductor. It drives your hypothalamus, it drives your cognition, but all of your neuromuscular junctions, every muscle movement, okay, is driven by acetylcholine, okay, so the neuromuscular junction, so Alzheimer's versus Parkinson's, for example. So when people get Alzheimer's disease, you go to an Alzheimer's facility, and you'll notice that they're all in wheelchairs, okay, so the loss, the loss of muscle function and the loss of cognition really go hand in hand and for the most part. So that's kind of where this gets really exciting. So, so the Alzheimer's thing, so we start talking about how we deal with Alzheimer's as functional component, right? The process of thinking, okay, is a process of walking, right? It's a thing. It's a function of the body, right? It's not a it's not a pathology. And so when we focusing on the neuropathology of Alzheimer's, like amyloid plaques and neurofibrillary tangles, these things happen after the fact. These are these are downstream. And things which they've been trying to develop drugs to remove those things, with very limited success, because they're not actually related to the function. So you restore the cholinergic system. And there's, you know, the plasmalogers are part of it, but the fossil, you know, choline methotransferase, and so there's, there's about four or five, really, core, you know, operating systems of the human body that you have to get right, your mitochondrial function. And I speak. And then so we do Biochemical Engineering, so we restore these things, we can measure them biochemically. And then the body starts, and the brain starts rebuilding itself, and so alter good. Now I have a

Dr. Spencer Baron:

question for you. I just want to because you've done so much, and you've accomplished some things that are very congruent with our our belief system, and as Dr Terry and I are healthcare providers in the chiropractic world. And you know, yet you have, and it seems so the answers you provide are so you know, consistent with what we believe that is the origin of a condition or a disease, instead of treating the symptoms. So where, where have you had your, your, your biggest conflict and debate with some of your peers, or you know, out you know others that practice, you know same or similar profession that you do, and because this is, I think, groundbreaking, but you've done it so long ago, right?

Dr. Terry Weyman:

How is it now? I was saying the same thing, it's what's taken. Why are they still treating it like they did in the 60s and 70s?

Dr. Dayan Goodenowe:

Well, now it comes down to the business and financial models of medicine. Okay, so I learned in the in the 2000 2000 10s and so, that when we were trying to get this colon cancer screening, because we F, you know, Health Canada approved diagnostic tests for colon, pancreatic, ovarian, launched them in Japan, for example, and so, and the the infrastructure to to deliver medicine, okay? And this is where the challenge comes in our industry as a whole, right? It's the it's how do we scale it and how we distribute it properly? And this is why I created program to deal with that very separately. So we've got a doctorate network over 3000 doctors. We recruit like 60 new doctors a month. Okay, so creating a parallel healthcare system is what we have to do, and we have to do it. We have to put the work in. Okay, that's one of the challenges of our industry, is that we like sometimes we get jaded, like we want to throw stones at the government or FDA and say, you know, you're just blocking all this stuff, but, you know, but there, you know, you have to give them. Your doctors have to be given something right, that's validated, distributable, you know. And so we have quite a bit of growth. So the the pushback we get from the traditional medicine field is kind of a more of a there's awareness part, but they really don't know what to do. So you got to be careful, because they, a doctor has rules that they have to follow, right? They have to prescribe. They have to they have guidelines, okay? They have, you know, the the you know, the organization, so you have to kind of work with them, okay, and fit into so obviously, a lot of practicing MDS in our in our network, so getting, you know, the biggest issue is having this delivery first part biochemistry is not taught. So we teach a lot, you know, getting people trained in basic biochemistry, because most doctors say, Oh, it's a supplement, okay, well, it's not just a supplement, okay? If you know, you think aldopa is a supplement, but you think it's a biggest thing on earth, well, because it's it's effective, it's actually restoring dopamine, makes sense, right? And so why would that be a legitimate thing, and restoring glutathione not legitimate, like we this, this controversy about both Tylenol, for example, in autism, right? Well, Tylenol is just a nasty, nasty drug. It should never been over the counter the first part, it's one of the most toxic things on the pharmacy aisle. Any kid that you drink who eats half a bottle Tylenol is going to die of liver disease, very cruel death, which is why every emergency room has, you know, IV and acetylcysteine to deal with acetaminophen overdoses. So the thought that, and we've known this since the beginning, so glutathione is the main detoxifier of Tylenol, and so you should be taking an acetyl if you do have to take Tylenol, which does work on headaches, like we all wouldn't be out there if it didn't have some effect, right? But you can take the antidote with the Tylenol. So take an acetylcysteine. If you take Tylenol, you have to take it. And we've known this from for a long time. Same thing with statins like CoQ 10 and mitochondrial function, you know, the mitochondrial myopathy that people get, the muscle wasting, muscle pain, muscle aches like there's and these side effects get just. Kind of under the carpet. I just did a big lecture on Parkinson's. 30% of people with Parkinson's get what's called Impulse control disorders, right? They'll, they'll have, they'll get addicted to gambling, or they'll have issues because you're, you're giving a bunch of dopamine. And how do we treat schizophrenia and bipolar with dopamine blockers? So you can imagine, if you're giving people a bunch of dopamine, you're basically stimulating the very areas that create bipolar, schizophrenic behaviors. And so about 30% of people will have these issues, right and so, and they don't know about these things like and so. And so I use a big lecture on the dopanergic You know, like, what do you what do you think is going to happen if you just dump a bunch of dopamine on human brain? Is it? How do you get in you know, there's positive and negative effects and so on and so forth. So I think back to your question, is bringing awareness. My job as an industrialist is scale. Okay? Like I have, I've taken on a whole city in Canada called Moose. In my hometown, we treat the whole city free of charge, okay? And is to deal with the epidemiological outcomes, because someone needs to do the work. And then here in Temecula, our facility will do clinical trials, like the formal type of trials. We'll have our MRI, we'll be able to run between one and 2000 patients anytime. And so, so going through this proper process, and this is the final point on this part, okay, wherever we go, it's the this type of medicine is undervalued, okay? Because we're all, we live in this cash pay business, chiropractor, you know, all that kind of stuff, right? And we know you get, you get results, right? So people, you line them up, and all of a sudden they feel better, and then it has a long term benefit, right? So they it's not just that they don't benefit from the day they're there. They have a long term progressive benefit from it afterwards. And we have gotten kind of suckered into pricing our work on a cost basis, okay, how much does it cost for my clinic? How much does it cost for this supplement? And that's why they're inexpensive versus charging for the value of the clinical outcome. Okay? ALS, for example, an average drug for ALS, is $150,000 a year. Okay, that's what? And they basically and they save doctor once every six months, if they're months, if they're lucky, okay? And all they do is they track their death. And this is a drug. These are drugs that that extend the life of the person by a few months. That's what they charge, okay? The MS drugs, you're doing 50, $60,000 the new drug for Alzheimer's, it does crap, okay? It causes brain bleeds, okay? It goes for 30 to $50,000 a year, with no support. That's just the bottle, okay? That doesn't, that doesn't, that doesn't charge for, that doesn't pay for the doctor's visit, doesn't pay for any follow up and all that kind of stuff, right? So, you know, so people go into these advanced technologies, they give it to stem cell or exosomes or biochemistry like, you know, understanding how they work. But if you can legitimately, reproducibly create an outcome, okay, we should be getting to a point where we can build these things based upon the proper market size, and that allows us to actually develop a business model for our doctors going forward, that if you can get an outcome, okay? Reproducibly the, this is where the So, this is why the distribution business model has to kind of follow through. Because we, we always end up, you know, I love going to a for m, I love going to the conferences. It's fun to see all the cool stuff that's out there. Like, you know, I, you know, I'm, I'm a geek. I love that kind of stuff, for sure, right? But, you know, it's kind of like, it's like, going to the bar in Star Wars, right? It's kind of feeling, it's like you're in that and so, but it's fun, right? I think sometimes we get into that fun stuff, and it's always this new thing, right? So, and, and there's this kind of this dopamine rush of what's the newest thing? If it's, is it hydrogen, water? Is it NAD? Is it just okay? And the thing is, they're all individually legitimate, but they work really well if you do them as a plan. And so anyways, so that's, that's where back to the business side of things is. That's why, back in 2016 I basically killed all my patents, this has to be a totally different model. We have to be able to do restorative health. And it's you can't go through an FDA path with with 15 products, okay, like, even, like it took forever to get the drugs for HIV done when you have a cocktail, from an FDA perspective, every single one has to go through individual, you know, testing, processing, even if it's natural right to get through that process. And so when you This is why we don't have a whole lot of multimodal programs. And so we'll be doing what's called a delayed start crossover design in our clinical trial structures. And so there are. Legitimate ways to do proper validation on that, but this type of restorative health and a community health model that deals with people before they get a disease, right? And I tell people, it's like when I my first, my first degree, our chemistry and was next to the engineering department, right? So every year the engineers did a 5050, fundraising. What they do? What they do is they take a beater car, they take a just an old beat up car, and they take the plug out of the oil. Okay? They drain the full oil out, and then you would bet on how many miles a car would drive before it seized up and stopped, right? So that's what they say so, and you'd be surprised at how far a car will drive with absolutely no oil in it, right? And so you think about that. And so when we very simple thing with dipstick, and you go, say, we don't wait for something when we know what the level is supposed to be, okay, then we fill it up. We don't wait for the engine to start knocking to say, Oh, I wonder what's causing knocking the engine. Oh, I guess I would have oil. I guess I should have fixed that. Why don't what? Well, I guess I better put some stuff in there to fix the piston rings now, because, you know, and I'll add this stuff here. And, oh, look, look at all this carbon build up from this. Well, what do you think? And so the So, this concept of prodromes is important, but this also gets into this health anxiety thing, your preventative maintenance. So my old car when I was a young kid, okay, yeah, I checked the oil. I checked the oil every time I got gas because it went through. But my new car, I don't check the oil every time. It's a waste of time, right? Because I know it's going to be fine, so I check it at the oil change, grab it. So now your preventative maintenance. So once you fix things, then you shouldn't have the anxiety like once you want, if you can measure your working system, you should be able to tailor your preventative maintenance schedule to that process. So so I'm kind of, you know, people getting these continuous monitoring and all these kind of, I think, creates a whole lot of stress on people. That's unnecessary, because once you get it working in your body, you shouldn't. You should have to be able to test less frequency frequently, right? Good. Now that's where my thing is

Dr. Spencer Baron:

earlier about, you know, the economics of of medicine. In a roundabout way, my curiosity is because of some of the things that you've discovered, patent and figured out, and even up to present time. Let's take a typical like colonoscopies, and then they came out with cologuard, which is now you could just send in a stool sample, and it's, you know, 98% accurate for detecting cancer early in the colon. But, you know, there must have been pushback by these, the the industry, the healthcare industry, that has advocated colonoscopies. So where has that? Where does that happen for you? I mean, what kind of pushback Have you experienced? Because, you know this, this is like revelation to you, and it's something that is so important is to, you know, do to identify before it becomes, you know, a necessity to get chemotherapy or things like that. You're going to get pushback. So what kind of experiences have

Dr. Dayan Goodenowe:

you had? The pushback comes from this, you know, have you got a randomized, clinical, randomized, controlled clinical trial, right? And they want to use this legitimate pharmacy model. The in terms of colon cancer is a good example. The like, I'm not a big fan of colonoscopies, so we showed who needed colonoscopy who didn't need colonoscopies, but you need a colonoscopy for the right people. So colon cancer was an issue of adherence, right people, you know, even taking the colon garbage, like, you know, poop in a box test, versus the, you know, fit test type thing, and that, you know, that they've been, they've been developing that for a long, long time, since the 90s. Exact sciences, and most of it's still blood, like 90% of the algorithm just deals with, you know, hemoglobin and stool, by the way, and the other biomarkers are, so I can get into the details on that one. But it's about adherence. It's about, you know, part of the health is, is getting people to believe in it, and right now, the pharmaceutical model is all fear based. People take things because they're afraid of what might happen if they don't take it, right, and they don't really know like, so you don't feel better, like, no one feels better with a statin. Okay, you don't take a statin and say, Wow, I feel great. You don't. No one does that, right, but you take it because your doctor says high LDL is bad, which is a total. That's another I can spend a whole day on on cholesterol. Just quickly, everyone should try to get their cholesterol between 220 and 250 that's your highest long term, your eight, your LDL should be over, over one. 20, and your HDL should be over 50, at least. And that is like 164 countries, highly reproducible. Local low cholesterol increases the risk of cancers, mortality. Soon as your cholesterol level gets under 20, under 200 okay, you're all cause mortality starts going up. And that is just a fact. Okay, it's not even arguable. And so this whole statin industry, but the point is, on this concept, though, is that they've convinced people, okay, with very fishy data, that LDL, like oxidized LDL and C reactive protein is an issue. That's true, but there's a big, big New England Journal paper. It's shocking to me that these really good studies get done, but then they get ignored. And that was the big lesson. Okay, just good science doesn't actually even really high level legitimate New England Journal of Medicine, large study. So New England Journal Medicine published a major paper, I think was 2007 like quite a while ago, showing that the benefit of a statin for cardiac outcome was only present in people who had C reactive protein levels over two if you had low levels of C reactive protein, there was no clinical benefit of taking a statin. Highly, highly clinically legitimate. So basically says that, hey, if you have high levels of oxidative stress, oxidized LDL, yes, it's a bad thing, because it goes in through the endothelial wall, creates atherosclerosis. Yes, we all get that. But if you don't have oxidative stress, your cholesterol has no relic. Do you guys know like if you have a familiar hypercholesterolester anemia. So these are people with cholesterol levels between 406 100. They have a longer lifespan than the regular population. So there's no mortality. There's no increased mortality. There is a slight increase in cardiovascular mortality, because if you have high levels of that cholesterol, LDL, specifically, you have and you and you then have some probability of having some oxidized stress. It's going to be amplified in that population. So I always make a joke about two people, like the call the oncologist, but cardiologist, a cardiologist, all they care about is that you don't die of cardiovascular disease. Okay, if you die of cancer, that's fine. But look at his heart, you know. Look at that like, you know you die of anything else, but so long as you don't die of cardiovascular disease, they don't really care is that, you know, you can die of anything else. But look at that, you know. And that's my joke about those guys,

Dr. Terry Weyman:

you know, Doc, I got go back to what you said, some fear, and we actually had a guest who had stage four breast cancer, and they wanted to do chemo and radiation, and insurance was going to pay. I think she ran that numbers was like $240,000 yet she went a different route and went to call holistic a better route. She paid $87,000 and was totally cured. And the frustration was she got so much pushback from the MD, so much pushback from people were yelling at her, how do we what? As a neuroscientist, how do we break the fear to look at alternatives that actually might save us?

Dr. Dayan Goodenowe:

I think you were in so cancer is a challenge. I have personal experience that with my dad. Okay, my dad got diagnosed with a advanced, diffuse B cell lymphoma, but the size of a quart in wrapped around his kidney and his ureter and all that kind of stuff, probably from a, well, from post covid, you know, Viterbo cancers that we're experiencing post covid type of thing. So he was given two months to live because it was growing so rapidly. And but cancer, and we were able to fix the cancer biochemically. And so cancer, all cancers are the same, whether it's breast cancer or liver cancer, it's the cell becomes like an anarchist. Basically, they don't, they don't behave the way they're supposed to behave, but they're all your cell, right? It's still cancer is interesting, because liver or a lung cancer cell is your cell. It's you, right? And it's lost its biochemical bearing, and so that success rate, so we I do a big lecture on breaking cancer, on biochemistry of cancer. So I've been able I treated him with no chemotherapy, shrunk it down, biggest thing for him to realize to be healthy during during his healing process and and so cancer is something absolutely predictability, the bracket gene I present, all that kind of stuff. So the pushback is that they, first of all, people, have egos, right? They'll have, they'll have, you know, they're experts, right? They go through expert training, and no one wants to know. You know, think about you go through 20 years, you've experienced like and you have certain levels of success, and some. Young buck comes up and telling you, well, everything you just learned, you've just been an idiot for being in school so long, right? It doesn't go over very well. Anybody. No one wants to hear that, right? I don't like to hear that either. I try to be open minded. But you know, you learn things, and our knowledge becomes a bias, right? Because we become less and less adaptable, and you build a career around things, like you have mortgages, you have things to do, right? And so you have hospitals that have bills to pay, and they have and it's all, you know. The thing with electric cars, for example, the reason why there's such a huge issue with those you know, apart whether they're valid or not, okay, apart from that, just from the infrastructure perspective, if everyone switched over to electric cars, well, oil changes would be gone. The the whole petrochemical all the all the gas stations, like, what happens to all those guys? Okay? Like, look at the economic trickle down, effect of just saying, instantly you're going to turn off. All you know, because, because the engines don't run on oil, the all this. So it has huge impacts, like real impacts on people's lives. So I think what I've done is work with people that you know, be respectful of, that professional in that space. You'll find people in those spaces that are open to it okay, and because I have leading neurologists and leading oncologists in our system, for sure, and it's a gradual process, and you see, and the problem is, they always get us into this anecdotal, you know, always anecdotal. It's just, these are just anecdotal case series type of thing, right? Yeah, great. Well, then then you got to, there's rules to the game, so we got to play within the rules, and so that's what building the infrastructure to do. And the biggest problem is that these cool things that we have the financial resources required to validate them to that level usually is beyond what these type of companies can do. We take an acetyl cysteine, for example, who's going to invest $10 million $10 million in an acetylcysteine? And you can buy it for two cents a pill. So some guy goes, improves this stuff. And there's lots of good clinical papers on that. But how do you protect it? That's my problem. So plasmid is a good example. So here's a cool story. So I discovered these plasmalogens, and because they're natural molecules, and the synthesis and the precursors are natural as well, right? Like human breast molecules, like plasmas and precursor, you can't patent naturally occurring molecules. So in order to patent them, you have to create a non natural molecule. So what I did was I created these gimmick molecules. So I created these so I took another natural molecule called alpha lipoic acid, which is a molecule that, you know, is necessary for the part of the pyruvate dehydrogenase pathway. And so I just put lipoic acid to the plasmalogen precursor, or the SN three position new molecule. I get patent the molecules, which I did, and then now that becomes an IP. So it's okay. This is great, you know, shopping to all the drug companies and did a whole bunch of preclinical work and and so on so forth. But the IP protection, but, you know, the problem is that you can kind of get around that, so that's why we've had to switch from an IP protected drug model to a service model, okay, in terms of, you know, the protocols, the infrastructure, the blood testing, the MRI, the knowledge of how to put pieces together, that's what we train through a doctor network that can be validated and packaged and and marketed at a price, at a price. So our doctor network, okay, they'll be the leading individuals when these things become reimbursable, and eventually they'll be free because the US healthcare budget. So people talk about, oh, look at Pfizer. Look at you know, we talk about Apple, or you talk about Google. Well, human health, the health care budget for the United States is$5 trillion a year. That's direct, 5 trillion in direct costs per year for health care in the United States that doesn't include secondary costs. That doesn't include, you know, a mom who's taking who has to stay home to take care of their autistic child doesn't doesn't doesn't include any of that stuff. These are just direct health care costs. If we can reduce the incidence of these diseases by 50% or more, okay, you're talking a multi trillion dollar industry, okay. It's bigger than any of these other industries out there, by far. And the value is that at a programmatic level, like the colon cancer programs or breast cancer screening programs. It becomes free, but there, the logistics of delivering has to get worked out. How do you work with a community, you know, like we're, you know, we have our own little bubble of advanced thinkers and tinker we like to tinker with things, but you. Down the street, and we all do that when we go to our family gatherings, right? Like, not everyone in our family believes it's either, right, they're all going to have they're going to say, Well, my doctor says this, right? So working with real regular people is how do you and that's what the community program in Moose Jaw is all about. So it takes a while, and there's going to be early adopters, and it's growing pretty rapidly. The world is really open to this covid really changed people. It kind of created this dichotomy, for example, like so clearly there was, like two, a split in thinking population, but it kind of Unmasked A lot of things for people, and it's created a critical mass of individuals who are really, you know, they're looking at things differently. They they assumed, I think everyone just assumed the government was looking after us. Everyone kind of assumed we did these things, and no one really knew that. We just don't have them. They remember, most of us, most people, live pretty healthfully for the most part. They don't complain, they get through their lives. And if you're not, something's wrong with you don't you're not paying attention. Who pays attention to colon cancer screening? Who doesn't have colon cancer? Okay? Who pays you don't pay attention that stuff, right? You just, kind of, you just kind of assume, Oh, someone's taking care of that. And then you realize, whoa, no, no one's taking care of this there's, there's, there's, yeah, the The Wizard of Oz, the guy's not there. Man, okay,

Dr. Terry Weyman:

Hey, Doc, I want for the you touch on some for the you know, when you go out your Think Tank and you go to your neighborhood, what? What would you what's the strategy to somebody listening right now that has a family history of Alzheimer's dementia and their family. What's a strategy that somebody could if you were to go down and talk to your normal neighborhood? What's the strategy somebody could do right now, after listening to show they start changing their trajectory.

Dr. Dayan Goodenowe:

So I focus on restoring their health. Like I've had people

Dr. Terry Weyman:

with Alzheimer's define that. What do you mean by restoring their health?

Dr. Dayan Goodenowe:

So people want to feel better and stronger, we want to get their independence back. Okay? And it's their caregiver. So it's going to be Alzheimer's is actually quite a challenge, because you don't actually treat the Alzheimer's patient. You treat the caregiver. Okay? No, no one with Alzheimer's is going to watch your podcast and say, Oh, I'm looking for someone. I'm looking for a solution.

Dr. Terry Weyman:

People that have a family member that died from it, thinking that they're going to get it may be listening correct,

Dr. Dayan Goodenowe:

and then we can, we can look at the predictability of it. But when, when you have a family with an Alzheimer's patient, it's going to be the caregiver that you treat, in a sense, and bring them up and there, and the you have to work with a codependency that the relationship has developed and then bring their independence back. I've had individuals that were under full conservatorship that now run their companies again. Okay, they've restored their cognitive skills to the point that they've actually taken their companies back. Okay? So we can, we know unambiguously we can restore cognition, mobility and function in people with Alzheimer's disease. You know, it's not it takes work. So the simple question, simple issue, is, for Alzheimer's disease, biochemistry, get your biochemistry right, food nutrition and these plasmalogen precursors, and you'll see these improvements. And it happens. So what we're doing the moose job, the problem with we have these, even if I have 3000 doctors or more now, they're dispersed everywhere. So you get a doctor in Dallas, you get a doctor in, you know, Pittsburgh, and they'll have a cohort of individuals that are getting better, and there's a little and it's kind of isolated. It's kind of like little pockets here and there, Moose Jaw. We're creating the situation where it's a defined geographic there's like 35,000 people in the general in the city, or 50 in the region, and they start seeing each other, okay? Their parents with these autistic kids that are going back to school, okay? And they talk locally, and they kind of but it's a year. We've been doing this for a year, over a year now, and we've had major successes. But the community takes but they start looking at this, and they start saying the fear of missing out, saying, well, they'll see people with post chemo going back, preaching at church and being fully functioning and and then they'll start saying, Okay, well, maybe that can be me. So it's about mentorship. Okay? People need to be able to see someone else, and then they kind of can follow that like, there's gonna be some people who don't need the mentorship. They'll just do it themselves, right? And that's the first people to come through our through our doors, but the rest of people, they really, it's a mentorship thing. They they they see someone else getting success, and they go, Wow, and it's local, right? It's not, it's not Instagram and Facebook, okay? That kind of gets people to your podcast and our webinars, but it's, it's when they go to the coffee shop or they go somewhere else to and they see someone they haven't seen for a couple months. They go, Whoa, you're looking pretty good. You know what's going on with you? And then they someone, and they chit chat, right? And they talk about things, and then. And then they come in, and I think there's no, there's no fast tracking that process, okay, human basic interaction takes time. So that part, I would say to any individual, is, look at some case studies. You know, you can come to our site, dr, Comm, and our petrol health, you know, case studies and the science behind it, but is that you want to respect life. This is the other pet peeve of mine in the elderly population. This this concept of, oh, you've lived a good life, or this concept of retirement, and no one should ever retire, retirement is basically putting a time. You're actually calculating the date of your death, basically saying, Okay, I'm done. I'm gonna I got 10 years. You have enough money to live for 10 years? Well, no, when you're when you're 90, you should be doing more than you were at 85 okay? You should never stop developing what you're doing, right? And you have a purpose in life. You have to get up and have a reason. And so this appreciation of life, and we've really, I think what's happened in the world is that the healthcare, 80% of the healthcare costs occur in the last few years of life, and people and governments are running out of money. They and so they're glorifying euthanasia at this point in time. I'm come from Canada. You know, medical assistance in Dying is like the second leading cause of death in whole country. You country. It's crazy. Okay, absolutely crazy. They're killing people left, right and center where I live. Oh, my God. Okay. And so it's, it's, it's, it's dehumanizing us in and so you should fight for your life. Life is precious. It's a gift that we've been given. And you should fight till the end, as long as you want, and getting people's purpose back, because, and you guys know this, okay, no amount of science, no amount of high tech, can keep a person alive if they don't want to be alive, if someone has given up on life, nothing is going to if you want to die, you will die, okay? And so if you want to live well, then you go to fight for it, okay? And you got to think about it, and you have a reason for you have to have a purpose. You have to have some excitement to get up in the morning. And so we got to give the elderly purpose and put get them involved. Okay? Because what are you going to do, you know, just play another game of canasta, like, you have to kind of get up, right? Like, you know, you can get reason to get involved in the community. So I think, I think we missed that component of things, and we live in this world of internet where we think we have 1000s of people doing this and that, but they're just kind of, they're not engaged. So I'm kind of the anti person of it's, we're kind of a bricks and mortar high labor type organization. Like you got to get people and you and, you know, when talking about chiropractors, people that actually touch people, and you're in, you're with people, right? You have to have, you have to have a love for people and and they're all different types and characters that you and some you don't, they're difficult, and some that are easy, but they gradually find their place. And I think that part is what we kind of try to infuse into people, that you're worth it, and so that's the other big thing. People don't think they're worth it. They don't really think a lot of people, dementia patients, they don't think they're worth saving, okay, and so. But if you can actually love that person and they feel valued, then they start actually valuing their own life. And then they start doing things that are healthy. They get up, they go for coffee with their friends. So if they're going to go for coffee with their friends, well they're going to get dressed now, oh, well, then maybe they're going to wash their face, and so they're going to do a bunch of others, and they're going to actually walk around a little bit. And so all these secondary things, like these social interaction, things that we talked about, well, they have a lot of lot of spin off issues, and then they want to do these things to be better. And they think, say, Okay, here's good nutrition, and they stick with it long enough to they can actually see these benefits. And we, and you need to capture these things, like video or with, with our assessments, because people always remember themselves well. They never remember themselves sick. And so if you don't say, Hold on, look at who you are right now. What's your baseline right now? This is what your function is. Don't forget where you are now. And then in a month, they say, Whoa, I'm doing a whole bunch more well. You're still not doing what you did when you're 30, but you did a heck of a heck of a lot more than you did a month ago. And then you got to calculate a win. You got to call a win a win, and so, but if they don't recognize, because, if they say nothing less than me skipping rope and rock climbing is a failure, well then every success is still a failure. Well, it's not enough. No, it's not enough. It's, you know, they're looking for some massive miracle in their life, and that steals their own successful trajectory from them, because, because they because they need to feel the wind, they need to feel the success that they're achieving. And we can do that with biochemical markers, but really the physiological ones are important, like we can show them. You know, we're fixing the biochemistry, but people need to find. Feel it in their own in their own world.

Dr. Spencer Baron:

Quick question, and you, you are obviously a healthcare provider and a motivator, which I believe is very important in the world of of healthcare is you don't just, you know, as chiropractors, even, even though we they think that we're just, you know, working on the physical or maybe even the nutritional, but we're also really working on inspiring the patient. And I appreciate what you have just shared. You mentioned something earlier too that aroused some curiosity, and that is, do you feel that of the last five or six years are people becoming more aware of what you what, what you're doing in the world of nutrition, let's say, or identifying conditions before they become, you know, a big blowout problem. Or are people getting sicker because of what's gone on the last five or six years?

Dr. Dayan Goodenowe:

Well, we're getting close to a tipping point. Okay, our Critical Mass is growing quite rapidly. And the doctor networks, because doctors talk with other doctors, and they're looking for things. Because everyone, no one, goes into medicine without wanting to help people, okay, like they're they want to. And you get tough cases like ALS and things like that. No one wants to be a failure. And so when these doctors saying, look, look at the success I'm getting, and their doctor, their practice, is getting better so that that that's a viral process, and that's happening at an exponential rate, okay, so that's really positive, and then the patient engagement is also happening at an exponential rate. We're getting close to tipping point, especially thinking something like autism on the other side of the equation. Yes, people are absolutely getting sicker. Okay, the this we have not hit the full wave of the post covid situation. Okay? Covid has done is it's like knocked everyone down 20 30% it's taken taking 20 to 30% of mitochondrial function across the board knocked everyone down. Okay, and now we're just waiting for age to kind of in time to start hitting people. And you're seeing and so people are. We have a lot more young people feeling less functional than before. All these chronic diseases were kind of old person issues, right? And it kind of got, oh, I'm just getting old. When 3040, year old people feel like crap. Well, it's not getting old. These people don't feel, Oh, I'm just getting old. No, they feel something's wrong. Okay, I'm not functioning. Okay? They're they're different. They don't, they don't, they don't chalk that up to age anymore, and we're seeing a lot of those individuals saying, Hey, this is not right. Something is just not adding up here. And so we are definitely seeing a far, far sicker population, and that's reaching its own tipping point. People are coming to the realization, like, what it's not working again. And I think some of it's subconscious at this point in time, and some of it's really conscious. But I think as a general rule, people are kind of saying, How can I have an iPhone? How can I have all these things that I have as massive technologies? And we haven't done dick on, on, on these chronic diseases. Really, we haven't. And someone's got, like, how can, how can we have, you know, SpaceX and all this kind of stuff. And we can't deal with simple diabetes, like, seriously, like, I'm and so I think people are kind of starting this, starting to add up in their head. They're just kind of, they're starting to really question and this basic philosophy, but then there's no replacement. Okay, you can't just go to people say, hey, it sucks to be you, you know, so you have to, so we need to be organized. So what we've done in our overall industries, we've lacked organization, we've lacked coherence, we've we've lacked some means of, and so I'm agnostic, right? We have, we kind of, I think, of what we've developed as these core platforms, biochemistry, some nutrition, objective measurements with MRI, but we're agnostic, so now you can plug in your favorite technology on top of that, but at least we can create some sort of basic structure of objective networking, right? And the doctors can all get involved in this thing. You know? We can. Another one of my pet peeves is biobanking your blood samples like you go, you get five blood, vials of blood, you send off to quest or with AP Corp, and they just throw it all in the garbage. Okay? You don't have, like, and you don't have and so we biobank everyone's blood sample that goes through our system, right? So you have your blood sample for the next 100 years. And so if you're healthy today, right? And then you get covid, or you get something said, Geez, what the heck happened to me? This happened with my dad. I was seven, tracking for years, right? And and then he gets this, this B cell, and I got to look at his old blood samples and go, Holy crap, look what. And so then I got to fix these. I got to put these things back to where they were. But still, this kind of tracking process, this is. This is what kind of when I'm talking about having a replacement strategy for people, that's what we're missing. People do recognize there's something is wrong, but we haven't created a legitimate replacement model for people, and that's because there's no place for people to go. Like, they have to go to the doctor, they have to go someplace. Like, where are they going to go and we have these functional net doctors around the world, and they can only do so much right, like they're not and and so that's, I think that's what we as an industry have to kind of struggle with, and just say, okay, yeah, so we're my job is slowly get us organized and and be open minded to what works. There's some really cool stuff I could do with lasers, or some, I'm working with some light therapy lenses, and so there's nothing. What we do is kind of like the, I call it the Ground Zero, like, you get the biochemistry right. It's kind of like, you know, you can't take some malnourished person from the Sub Saharan Africa and put them in boot camp and expect to get a soldier out of the person right? Like, you need to be able to need, need to be able to actually deliver like so when you stimulate the body and you do the exercise that you're supposed to do, you do your body has to be able to actually deliver on what you're asking it to do. Okay? And so if you give an exosome, which is giving some some new genetic material, or young genetic material, or young genetic material, and it's going to stimulate a cell. Well, that cell has to act. Or you give stem cell, they tell people, stem cells are like throwing a bunch of puppies in with old dogs. And all of a sudden, these old dogs see these young puppies and say, Well, I want to be puppy again. And so they start acting like a puppy. And so, but you need to be able to those old dogs need to actually be able to perform like the puppies that you're putting in there, and so they can sustain it. And so what we do is, really at the base level, is, can we, can we enable the core infrastructure to do its job, so that these other technologies that have true validity, they can be used in the right circumstance, in the right person, in a highly reproducible way? And think that's kind of what my passion is. You know, other than the science type, which is still cool, and working with these rare disease children and I get an opportunity to work with so many amazing people, is really try to build this infrastructure.

Dr. Spencer Baron:

Dr, good. Now let me we're going to wind down the program, but we always have this section that makes light and fun of some things that may be personal to you that's off of such an intense subject like this. We call it the rapid fire questions. And although we have probably have a ton of other questions for you based on our original subject matter, we're going to end the show with five questions that you would have to answer in a few words or less, which that may be difficult. Okay, if you're ready, here we go. What is one character trait or personality type that you noticed today during your scientific journey that you had in when you were a young, young child.

Dr. Dayan Goodenowe:

Well, Curiosity is number one thing is just really and realizing that you the more, the more you know, the more you don't know, right? And we have to unlearn, to learn like we have. We have to really be sensitive our own biases, like as we educate ourselves. We have to, we really have to knock down our own bias, our own cockiness, and we have to realize that, you know, we could be wrong. We could find solutions. And I think that's the the that's the biggest thing right there.

Dr. Spencer Baron:

Question number two, if there was one lifestyle, variable, sleep, diet, movement, stress, and you wanted to see a 30% effect on cognition, which one would you pick?

Dr. Dayan Goodenowe:

Oh, easy, muscle density. So absolutely the number one thing maintaining maintaining skeletal muscle mass with life is the most important thing. It prevents diabetes. It reduces cancer rates. It improves cognition. Maintaining skeletal muscle mass with aging. So regular resistance training, go for your walks, go cardiovascular training, all you want, okay, but twice a week lift weights, like people have to be lifting weights. Okay, maintaining skeletal muscle is the number one thing of aging that you have to do.

Dr. Terry Weyman:

I'm screwed. Dr, Spencer's gonna live forever.

Unknown:

Dr, good. Now he's the best

Dr. Spencer Baron:

question number three, what is, if there's a possibility, what is the dumbest question you've ever been asked about your work, and what would your answer be? You know, you know, obviously biting the lip there,

Dr. Dayan Goodenowe:

but yeah, well, it's, it's actually, it's not. It's a dumb question in retrospect, but it's not a dumb question. When you when you do it the first time. And the biggest question I have is, okay, I'm going to take these supplements. How long do I have to take them? Okay? When can I stop taking them? Okay? And then I say, well, when do you stop eating protein? Okay, when do you stop drinking water? Okay? Like you're a human biochemical system, like you are a bioreactor, like you're basically taking hydrocarbons in your body, like your furnace, and you're breathing out carbon dioxide, and you're peeing out water, okay? And so, so, yeah, so it's forever, so if you, if you want so, and I think people, they because they think again. They think of something. They think of food, nutrition, almost like a drug, right? Oh, I'm going to take it to get better, okay? And then once I'm better, I don't need anything anymore. Well, go, no, well, no, the reason why you got better is because you're taking these things. So, so you don't, don't stop, and so, but so it seems like such an innocent question, and they go, oh, oh, yeah, yeah, I guess you know,

Dr. Spencer Baron:

I love your earlier, your car analogy with the oil. I'm definitely going to use that on most of the male patients that come in, because they would totally understand that that was great with the dipstick. The old days, we would look at a dipstick every time we would stop and get cat. All right. Question number four, if you weren't a scientist or an entrepreneur, what odd or maybe surprising profession would you have secret? Would you secretly have have chosen or want to do?

Dr. Dayan Goodenowe:

Oh, easy. I'm a farmer. I'm a farm kid. I grew up. I grew up on a horse's back and a hockey ring, okay, and so, and actually, that's my main love. I built two farms to finance the companies I built, and I had, I built the farms up, and then I sold the farm. And so I basically, I'm a scientist out of guilt, okay, really, it's, it's if I, if I was, be truly selfish, I wouldn't be here. I'd be on a tractor on my farm, okay? And I would be just because, you know, I love people, but I don't kind of really like people that much. I love being around them, but I truly, you have to have love in this world. But so the thing is, with but you can't unknow what you know, right? And so I have these rare just like these plasmalogists, there's kids dying. There's literally kids and they're alive today. They're growing, they're developing. Their brains are normal. And this is, this is what really drives me crazy, gives me so many sleepless nights. So the one rare disease I work with a lot of children's rare diseases, we can bypass them. I've got some really interesting studies and Down Syndrome happening, but one particular one, RCTV, so rhizomatic chondrodysplasia punctata. It's a disease that has a mutation in plasmalogen manufacturing. Everything else with these kids is normal, okay, but they have, they have a genetic mutation that they can't make plasminogens, or they can make very little plasmalogens. Our molecules are the absolute antidote to this disease. You take our plasmalogens, you don't have the disease. It's that. It's that EFF and simple. And I have number of, the number of families who don't take this supplement, okay, because the neurologist, or whatever else, and they and they'll just kind of, it's like, well, I'm this. I'm gonna do what my doctor says, yeah, don't, don't blame me because my child died. I just did what I was told. Like, seriously, it's like, Okay, I'm gonna and so, so we have these children that were in our system, and they they're alive because of what I manufacture every day. And so I can't be on my tractor at home, because until these things get out there. Okay, I can't, you know, you can't unknow these things. And it's a really, it's a big challenge. It's, it's really, you know, you can't, you want to help people, and then they don't want to help themselves. And it's, and you have to kind of just kind of be patient and take love with it, but, but that's, yeah, so me, my personal perspective. I'm a farm kid. I love being in the dirt, and I love time out there, so

Unknown:

cows and chickens over people. I got you. I'm with you on this. All right, if you're on Instagram, it's all cats and dogs, right, right? Yeah, oh, yeah.

Dr. Spencer Baron:

Like last last question, last question. This has been fantastic. Last question, what is one book or film or maybe piece of art that you wish everyone would maybe carry in their back pocket?

Dr. Dayan Goodenowe:

Oh, my goodness, here's that. A couple. I've always gravitated to, Atlas Shrugged by Ayn Rand, and the old one was basically this, this purposefulness, right? It's a it's a great lesson on, on where we are today, highly predictive. And then the Buddhist aspect. I am born, you know, raised Christian in my life, and now with quantum mechanics, but Buddhism and the Bodhidharma is, it's the Zen teaching of Buddha. Dharma is an incredible little book that just kind of teach, kind of is a reality check that what you know, what, what's purposefulness, okay? Those, those philosophical things that kind of get you out of your ego. Right? And you really get yourself this, this concept of providing service, and service has so much power. Okay? We live in, I always tell people, self help is killing us, this concept of everyone trying to get self help and what's good for them, and they think that that's actually going to benefit them long term in their life. And you really benefit from the people around you that you help, okay? And to live a life of service, create such, such an amplification of yourself. And so do you want to have an ego? Have an ego in your lack of ego, basically, in the fact that you can just open your heart up to people and help and it universe comes back to you. I think we've lived in this thing. We've we've stuck people into, you know, take what's yours, get your piece of the pie. You know, self help on this. And you know, you're worth it. You're it's all about what you're worth, right? And really, the only worth any of us have is our reflection in others. Okay? Otherwise, we don't exist. We really don't exist, except in how how we reflect on others around us, I think understanding that kind of and the strength and power that comes from it, because then you have to worry about it. You go to bed at night. You get up in the morning. You do what you can during your day, okay? You put an honest effort into what you do, whether wherever you are, and you sleep well at night, and people get caught up into the complexities of this world, and it creates the stress of this world. And lot of the stress is from our wanting things for ourselves. And I think that, in a really weird way, gives you much more strength. I think that's kind of, I think when you you find a right place to put that, and this gives you the purpose we talked about early on, right? Because if your purpose is only for yourself, that runs out pretty soon, like, you know, what are you gonna live by yourself in an island? Or what are you gonna do like you're gonna like? So finding this purpose, if your purpose is helping others, that's never ending, that's an infinite purpose like that, that never like you can be 300 years old and still do that purpose, right? And I think those are the things that and so this longevity and immortality, like, if you're going to live a long time, you got to figure what the hell you're going to do for a long time. So if you want to live to be 200 What the hell are you going to do when you're 150 like, what's, what's, what's your plan? Okay, is it how many, how many rounds of golf Can you play like? You have to be like. You have to have some purpose. And so you have to figure out, you have to think of a purpose that's going to sustain you. You can change. You know different things will happen in your life, but something that is has enough longevity to it that can be beyond your livability, right? So you have to, you have to have plans in your life that are longer than your lifespan.

Dr. Spencer Baron:

Yes, agreed. That was fantastic. Listen. Thank you so so much, and I know that Dr Terry and I, we probably have more questions that we could have asked you about the bulk of the conversation, but maybe another time. But thank you so much for your time. This was really, really enlightening and very congruent with what we feel.

Dr. Dayan Goodenowe:

I'm excited to work with you guys and just, you know, that's it's a fun world of it. And what's so cool is you find each other, like we actually this world is funny. Like you more you live in it. You realize less and less coincidences there are, like you find people and something draws us together. And it's pretty exciting to see so really

Dr. Spencer Baron:

phenomenal. Thank you so much. Very welcome. Bye.